Mariners vs. Royals prediction: Seattle favored to win Tuesday's MLB matchup [9/16/2025]

The Kansas City Royals and Seattle Mariners will lock horns in MLB action at Kauffman Stadium on Tuesday, starting at 7:40PM ET.

The Royals will send Michael Wacha (9-11, 3.45 ERA) to the mound, while the Mariners have opted for Logan Gilbert (4-6, 3.54 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Mariners as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Mariners vs. Royals predictions page.

Royals vs. Mariners prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Mariners and Royals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Mariners a 54% chance of defeating the Royals.

According to our model, the Royals (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of going over.

Mariners vs. Royals odds [9/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Royals
Run Line	-1.5 (+123)	+1.5 (-140)
Moneyline	-136	+120
Total	o8.5 (-108)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Royals picks and best bets

Our model's strongest edge in today's Mariners vs. Royals matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Mariners vs. Royals game-day updates and essential details

Tuesday's MLB action between the Royals and Mariners at Kauffman Stadium is scheduled to commence at 7:40PM ET.

• Who: Seattle Mariners vs. Kansas City Royals
• Date: Tuesday, September 16, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Kauffman Stadium

Dimers' comprehensive preview of Tuesday's Mariners vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Royals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mariners, with a 54% win probability, will likely beat the Royals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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