Mariners vs. Astros prediction: Cy Young candidate Hunter Brown takes on Seattle tonight [9/19/2025]

The Houston Astros will face the Seattle Mariners, in what is expected to be a close MLB game, at Daikin Park on Friday, beginning at 8:10PM ET.

Cy Young hopeful Hunter Brown (12-7, 2.27 ERA) will get the ball for the Astros, up against fellow hopeful Bryan Woo (14-7, 3.02 ERA) for the Mariners.

Based on updated simulation results, Dimers' proven MLB model predicts the Astros as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Mariners vs. Astros predictions page.

Astros vs. Mariners prediction: Who will win?

Using innovative machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Mariners and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Astros a 53% chance of defeating the Mariners.

According to our model, the 7.5-run over/under has a 55% chance of going over.

Mariners vs. Astros odds [9/19/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Astros
Moneyline	-107	-108
Total	o7.5 (+100)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Astros picks and best bets

Our model's strongest edge in today's Mariners vs. Astros matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Mariners vs. Astros game-day updates and essential details

Friday's MLB matchup between the Astros and Mariners at Daikin Park is scheduled to begin at 8:10PM ET.

• Who: Seattle Mariners vs. Houston Astros
• Date: Friday, September 19, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers' full preview of Friday's Mariners vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 53% win probability, will likely beat the Mariners on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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