Mariners vs. Astros Prediction: Seattle Predicted to Win Thursday's MLB Matchup [5/22/2025]

The Houston Astros will face the Seattle Mariners, in what is expected to be a close MLB game, at Daikin Park on Thursday, commencing at 8:10PM ET.

Lance McCullers (0-1, 7.88 ERA) will be on the bump for the Astros, pitting him against George Kirby (0-0, 0.00 ERA) for the Mariners.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Mariners as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Seattle-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Mariners with a win probability of 53% and the Astros with 47%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Mariners vs. Astros predictions page.

Astros vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Thursday's MLB game between the Mariners and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mariners a 53% chance of beating the Astros.

According to our model, the Astros (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 52% chance of going over.

Mariners vs. Astros Odds [5/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Astros
Run Line	-1.5 (+130)	+1.5 (-142)
Moneyline	-130	+116
Total	o8 (-110)	u8 (-106)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Astros Picks and Best Bets

Our model's strongest edge in today's Mariners vs. Astros matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Mariners vs. Astros Game-Day Updates and Essential Details

Thursday's MLB action between the Astros and Mariners at Daikin Park is scheduled to start at 8:10PM ET.

• Who: Seattle Mariners vs. Houston Astros
• Date: Thursday, May 22, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Thursday's Mariners vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Mariners, with a 53% win probability, will likely beat the Astros on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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