Mariners vs. Astros Prediction: Houston Predicted to Win Saturday's MLB Matchup [5/24/2025]

The Houston Astros will take on the Seattle Mariners, in what is expected to be a close MLB game, at Daikin Park on Saturday, beginning at 4:10PM ET.

Framber Valdez (3-4, 3.57 ERA) will start on the mound for the Astros, pitting him against Bryan Woo (5-1, 2.65 ERA) for the Mariners.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Seattle-Houston game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Astros are more likely to win, while the Mariners have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Mariners vs. Astros predictions page.

Astros vs. Mariners Prediction: Who Will Win?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's MLB game between the Mariners and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 54% chance of beating the Mariners.

According to our model, the over/under total of 7 runs has a 52% chance of going over.

Mariners vs. Astros Odds [5/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Astros
Moneyline	-110	-105
Total	o7 (-122)	u7 (+105)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Astros Picks and Best Bets

Our model's biggest edge in today's Mariners vs. Astros matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Mariners vs. Astros Game-Day Updates and Essential Details

Saturday's MLB game between the Astros and Mariners at Daikin Park is scheduled to start at 4:10PM ET.

• Who: Seattle Mariners vs. Houston Astros
• Date: Saturday, May 24, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Saturday's Mariners vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 54% win probability, will likely beat the Mariners on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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