Mariners vs. Astros Prediction: Houston Predicted to Win Friday's MLB Matchup [5/23/2025]

The Houston Astros will square off with the Seattle Mariners, in what is expected to be a tight MLB game, at Daikin Park on Friday, commencing at 8:10PM ET.

Ryan Gusto (3-2, 4.64 ERA) will be the starting pitcher for the Astros, while the Mariners have opted for Emerson Hancock (1-2, 6.21 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Astros as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Seattle-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Astros' chance of winning is 54%, while the Mariners' is 46%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Mariners vs. Astros predictions page.

Astros vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Mariners and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Astros a 54% chance of defeating the Mariners.

According to our model, the Mariners (+1.5) have a 64% chance of covering the run line, while the over/under total of 8.5 runs has an equal 50-50 chance of hitting.

Mariners vs. Astros Odds [5/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Astros
Run Line	+1.5 (-200)	-1.5 (+165)
Moneyline	+102	-116
Total	o8.5 (-118)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Astros Picks and Best Bets

Our model's strongest edge in today's Mariners vs. Astros matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Mariners vs. Astros Game-Day Updates and Essential Details

Friday's MLB game between the Astros and Mariners at Daikin Park is scheduled to commence at 8:10PM ET.

• Who: Seattle Mariners vs. Houston Astros
• Date: Friday, May 23, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's comprehensive preview of Friday's Mariners vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Astros, with a 54% win probability, will likely beat the Mariners on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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