Mariners vs. White Sox Prediction: Seattle Predicted to Win Tuesday's MLB Matchup [5/20/2025]

The Chicago White Sox will square off with the Seattle Mariners in MLB action at Rate Field on Tuesday, beginning at 7:40PM ET.

Adrian Houser (0-0, 0.00 ERA) will be the starting pitcher for the White Sox, while the Mariners have opted for Casey Legumina (3-1, 1.84 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Mariners as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Seattle-CHI White Sox game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Mariners with a win probability of 58%, compared to 42% for the White Sox."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Mariners vs. White Sox predictions page.

White Sox vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Mariners and White Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Mariners a 58% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 54% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Mariners vs. White Sox Odds [5/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	White Sox
Run Line	-1.5 (-110)	+1.5 (-105)
Moneyline	-180	+154
Total	o8.5 (-105)	u8.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Mariners vs. White Sox matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Mariners vs. White Sox Game-Day Updates and Essential Details

Tuesday's MLB game between the White Sox and Mariners at Rate Field is scheduled to start at 7:40PM ET.

• Who: Seattle Mariners vs. Chicago White Sox
• Date: Tuesday, May 20, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Tuesday's Mariners vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Mariners, with a 58% win probability, will likely beat the White Sox on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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