Mariners vs. Cubs Prediction: Seattle Predicted to Win Sunday's MLB Matchup [6/22/2025]

The Chicago Cubs and Seattle Mariners will lock horns in MLB action at Wrigley Field on Sunday, starting at 2:20PM ET.

Colin Rea (4-2, 3.84 ERA) will start on the mound for the Cubs, while the Mariners have opted for Logan Gilbert (1-2, 2.55 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Mariners as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Mariners-Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Mariners with a win probability of 52%, while the Cubs have 48%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Mariners vs. Cubs predictions page.

Cubs vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Mariners and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mariners a 52% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 59% chance of covering the run line, while the over/under total of 11.5 runs has a 59% chance of staying under.

Mariners vs. Cubs Odds [6/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Cubs
Run Line	-1.5 (+130)	+1.5 (-144)
Moneyline	-125	+105
Total	o11.5 (-102)	u11.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Mariners vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Mariners vs. Cubs Game-Day Updates and Essential Details

Sunday's MLB game between the Cubs and Mariners at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Seattle Mariners vs. Chicago Cubs
• Date: Sunday, June 22, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Sunday's Mariners vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Mariners, with a 52% win probability, will likely beat the Cubs on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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