Mariners vs. Cubs Prediction: Cubs Predicted to Win Saturday's MLB Matchup [6/21/2025]

The Chicago Cubs will take on the Seattle Mariners in MLB action at Wrigley Field on Saturday, commencing at 2:20PM ET.

The Cubs will send Cade Horton (3-1, 3.47 ERA) to the mound, while the Mariners have opted for Emerson Hancock (3-2, 4.48 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Mariners-Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cubs are more likely to win, while the Mariners have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Mariners vs. Cubs predictions page.

Cubs vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Saturday's MLB game between the Mariners and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 61% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 55% chance of covering the run line, while the over/under total of 12.5 runs has a 59% chance of staying under.

Mariners vs. Cubs Odds [6/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Cubs
Run Line	+1.5 (-130)	-1.5 (+113)
Moneyline	+145	-157
Total	o12.5 (-105)	u12.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Mariners vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Mariners vs. Cubs Game-Day Updates and Essential Details

Saturday's MLB game between the Cubs and Mariners at Wrigley Field is scheduled to commence at 2:20PM ET.

• Who: Seattle Mariners vs. Chicago Cubs
• Date: Saturday, June 21, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Saturday's Mariners vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 61% win probability, will likely beat the Mariners on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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