Mariners vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [6/20/2025]

The Chicago Cubs will square off with the Seattle Mariners in MLB action at Wrigley Field on Friday, starting at 2:20PM ET.

The Cubs will start Matthew Boyd (6-3, 2.79 ERA), up against George Kirby (1-3, 5.96 ERA) for the Mariners.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Mariners-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cubs' chance of winning is 57%, while the Mariners' is 43%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Mariners vs. Cubs predictions page.

Cubs vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Mariners and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 57% chance of defeating the Mariners.

According to our model, the Mariners (+1.5) have a 61% chance of covering the run line, while the over/under total of 11.5 runs has a 71% chance of staying under.

Mariners vs. Cubs Odds [6/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	Cubs
Run Line	+1.5 (-161)	-1.5 (+150)
Moneyline	+120	-136
Total	o11.5 (-108)	u11.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Mariners vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Mariners vs. Cubs Game-Day Updates and Essential Details

Friday's MLB matchup between the Cubs and Mariners at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Seattle Mariners vs. Chicago Cubs
• Date: Friday, June 20, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Friday's Mariners vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Mariners vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Mariners on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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