Santos Laguna vs. San Luis prediction, odds, Liga MX picks [9/21/2025]

Santos Laguna will square off with Atletico San Luis in Liga MX action on Sunday, commencing at 7:00PM ET.

Based on updated simulation results, Dimers' proven Liga MX model predicts San Luis as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Santos Laguna-San Luis game," said Dave Garofolo from Dimers.

"Taking into account the most current updates and numerous additional factors, our prediction gives Santos Laguna a 36.2% chance of winning, Atletico San Luis a 39.0% chance, and a 24.9% chance of a draw."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Santos Laguna vs. Atletico San Luis predictions page.

Santos Laguna vs. Atletico San Luis prediction: Who will win?

Using innovative machine learning and data, we have simulated the result of Sunday's Liga MX game between Santos Laguna and Atletico San Luis 10,000 times as part of our Liga MX predictions coverage.

Our famous predictive model indicates a 36.2% chance of Santos Laguna winning, a 39.0% chance for Atletico San Luis, and a 24.9% chance of a draw.

Additionally, the 2.5-goal over/under has a 55% chance of going over, according to our model.

Santos Laguna vs. Atletico San Luis odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Santos Laguna	Atletico San Luis	Draw
+155	+165	+250

Total Goals

Over 2.5	Under 2.5
-148	+120

All odds are correct at the time of publication and are subject to change.

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Santos Laguna vs. Atletico San Luis picks and best bets

Our model's biggest edge in today's Santos Laguna vs. Atletico San Luis matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Santos Laguna vs. Atletico San Luis: Correct score and BTTS predictions

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

Final Score	Probability
SLA 1-1 ASL	11.6%
SLA 1-2 ASL	8.6%
SLA 2-1 ASL	8.2%

When it comes to the both teams to score (BTTS) market, we project a 58.3% chance that both teams scoring, and a 41.7% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations, meaning the most likely correct score can differ from our predicted winner.

Santos Laguna vs. San Luis game-day updates and essential details

Sunday's game between Santos Laguna and Atletico San Luis is scheduled to begin at 7:00PM ET.

• Who: Santos Laguna vs. Atletico San Luis
• Date: Sunday, September 21, 2025
• Time: 7:00PM ET/4:00PM PT

Dimers' comprehensive preview of Sunday's Santos Laguna vs. Atletico San Luis matchup includes our prediction, picks and the latest betting odds.

Before making any San Luis vs. Santos Laguna picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

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Conclusion

According to our computer model, Santos Laguna has a 36.2% win probability on Sunday, Atletico San Luis has a 39.0% win probability, and there is a 24.9% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Santos Laguna vs. Atletico San Luis insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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