San Luis vs. Club America prediction, odds, Liga MX picks [9/24/2025]

Atletico San Luis will face Club America in Liga MX action on Wednesday, commencing at 11:00PM ET.

Based on the latest simulation results, Dimers' advanced Liga MX model predicts Club America as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Luis-Club America game 10,000 times," said Dave Garofolo from Dimers.

"Taking into account the most current updates and numerous additional factors, our prediction gives Atletico San Luis a 20.5% chance of winning, Club America a 57.8% chance, and a 21.6% chance of a draw."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Atletico San Luis vs. Club America predictions page.

Atletico San Luis vs. Club America prediction: Who will win?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's Liga MX game between Atletico San Luis and Club America 10,000 times as part of our Liga MX predictions coverage.

Our leading predictive model indicates a 20.5% chance of Atletico San Luis winning, a 57.8% chance for Club America, and a 21.6% chance of a draw.

Additionally, the 2.5-goal over/under has a 59% chance of going over, according to our model.

Atletico San Luis vs. Club America odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

Moneyline

Atletico San Luis	Club America	Draw
+380	-145	+310

Total Goals

Over 2.5	Under 2.5
-142	+116

All odds are correct at the time of publication and are subject to change.

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Atletico San Luis vs. Club America picks and best bets

Our model's strongest edge in today's Atletico San Luis vs. Club America matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Atletico San Luis vs. Club America: Correct score and BTTS predictions

The top three most likely final scores, according to our model, are listed below, with a 1-1 draw being the most probable:

Final Score	Probability
ASL 1-1 AME	10.1%
ASL 1-2 AME	9.9%
ASL 0-1 AME	9.2%

When it comes to the both teams to score (BTTS) market, we project a 57.2% chance of the yes hitting, and a 42.8% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations, which means the most likely correct score may differ from our predicted winner.

San Luis vs. Club America game-day updates and essential details

Wednesday's action between Atletico San Luis and Club America is scheduled to begin at 11:00PM ET.

• Who: Atletico San Luis vs. Club America
• Date: Wednesday, September 24, 2025
• Time: 11:00PM ET/8:00PM PT

Dimers' comprehensive preview of Wednesday's Atletico San Luis vs. Club America matchup includes our prediction, picks and the latest betting odds.

Before making any Club America vs. San Luis picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Atletico San Luis has a 20.5% win probability on Wednesday, Club America has a 57.8% win probability, and there is a 21.6% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Atletico San Luis vs. Club America insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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