Giants vs. Nationals Prediction: San Francisco Predicted to Win Saturday's MLB Matchup [5/24/2025]

The Washington Nationals and San Francisco Giants will lock horns in MLB action at Nationals Park on Saturday, starting at 4:05PM ET.

The Nationals will have Jake Irvin (3-1, 3.88 ERA) as their starting pitcher, pitting him against Kyle Harrison (0-0, 3.38 ERA) for the Giants.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's San Francisco-Washington game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Giants are more likely to win, while the Nationals have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Giants vs. Nationals predictions page.

Nationals vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Giants and Nationals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Giants a 58% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 56% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Giants vs. Nationals Odds [5/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Nationals
Run Line	-1.5 (+108)	+1.5 (-125)
Moneyline	-155	+135
Total	o8.5 (-102)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Nationals Picks and Best Bets

Our model's strongest edge in today's Giants vs. Nationals matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Giants vs. Nationals Game-Day Updates and Essential Details

Saturday's MLB matchup between the Nationals and Giants at Nationals Park is scheduled to begin at 4:05PM ET.

• Who: San Francisco Giants vs. Washington Nationals
• Date: Saturday, May 24, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Saturday's Giants vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Giants, with a 58% win probability, will likely beat the Nationals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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