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Giants vs. Nationals Prediction: Washington Predicted to Win Friday's MLB Matchup [5/23/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Our expert prediction for Friday's San Francisco Giants vs Washington Nationals matchup.
The Washington Nationals and San Francisco Giants will lock horns in MLB action at Nationals Park on Friday, starting at 6:45PM ET.
The Nationals will start MacKenzie Gore (2-4, 3.68 ERA), while the Giants are going with Landen Roupp (2-3, 4.11 ERA).
Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Nationals as the most likely winner of today's game.
"Employing the latest data, our experts simulated Friday's San Francisco-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"After computing the latest updates and thousands of other inputs, we predict the Nationals' chance of winning is 54%, while the Giants' is 46%."
For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Giants vs. Nationals predictions page.
Nationals vs. Giants Prediction: Who Will Win?
Using innovative machine learning and data analysis, we have simulated the outcome of Friday's MLB game between the Giants and Nationals 10,000 times as part of our MLB predictions coverage.
Our leading predictive model gives the Nationals a 54% chance of beating the Giants.
According to our model, the over/under total of 7.5 runs has a 52% chance of going over.
Giants vs. Nationals Odds [5/23/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Giants | Nationals |
|---|---|---|
| Moneyline | -102 | -112 |
| Total | o7.5 (-120) | u7.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Giants vs. Nationals Picks and Best Bets
Our model's biggest edge in today's Giants vs. Nationals matchup is on the moneyline.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets
Calling Our Shot produces daily MLB betting content, including the predictions featured below.
Giants vs. Nationals Game-Day Updates and Essential Details
Friday's MLB game between the Nationals and Giants at Nationals Park is scheduled to start at 6:45PM ET.
- Who: San Francisco Giants vs. Washington Nationals
- Date: Friday, May 23, 2025
- Time: 6:45PM ET/3:45PM PT
- Venue: Nationals Park
Dimers.com's comprehensive preview of Friday's Giants vs. Nationals matchup includes our prediction, picks and the latest betting odds.
Before making any San Francisco vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Nationals, with a 54% win probability, will likely beat the Giants on Friday.
AI and automation have enhanced this article to quickly deliver accurate Giants vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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