Giants vs. Cardinals prediction: St. Louis favored to win Friday's MLB matchup [9/5/2025]

MLB action continues on Friday at 8:15PM ET as the San Francisco Giants take on the St. Louis Cardinals at Busch Stadium.

The Cardinals will have Michael McGreevy (6-2, 4.17 ERA) as their starting pitcher, while the Giants have opted for Carson Seymour (0-2, 4.74 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Cardinals as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Giants vs. Cardinals predictions page.

Cardinals vs. Giants prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Giants and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cardinals a 52% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 67% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Giants vs. Cardinals odds [9/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Cardinals
Run Line	+1.5 (-220)	-1.5 (+165)
Moneyline	+100	-116
Total	o8.5 (-104)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Cardinals picks and best bets

Our model's biggest edge in today's Giants vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Giants vs. Cardinals game-day updates and essential details

Friday's MLB action between the Cardinals and Giants at Busch Stadium is scheduled to begin at 8:15PM ET.

• Who: San Francisco Giants vs. St. Louis Cardinals
• Date: Friday, September 5, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Friday's Giants vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 52% win probability, will likely beat the Giants on Friday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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