Giants vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [4/30/2025]

MLB action continues on Wednesday at 4:10PM ET as the San Francisco Giants lock horns with the San Diego Padres at PETCO Park.

The Padres will send Michael King (3-1, 2.18 ERA) to the mound, up against Landen Roupp (2-1, 4.56 ERA) for the Giants.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Francisco-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 56%, with the Giants at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

Padres vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 56% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 64% chance of covering the run line, while the 7-run over/under has a 51% chance of staying under.

Giants vs. Padres Odds [4/30/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Padres
Run Line	+1.5 (-190)	-1.5 (+164)
Moneyline	+120	-140
Total	o7 (-105)	u7 (-110)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Padres Picks and Best Bets

Our model's biggest edge in today's Giants vs. Padres matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Giants vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB game between the Padres and Giants at PETCO Park is scheduled to start at 4:10PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Wednesday, April 30, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Wednesday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 56% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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