Giants vs. Padres prediction: San Diego predicted to win Wednesday's MLB matchup [8/20/2025]

The San Diego Padres and San Francisco Giants are scheduled to meet in MLB action at PETCO Park on Wednesday, starting at 9:40PM ET.

JP Sears (7-10, 5.12 ERA) will start for the Padres, pitting him against Landen Roupp (7-6, 3.45 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Giants-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 60%, with the Giants at 40%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

Padres vs. Giants prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Padres a 60% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 59% chance of covering the run line, while the 8-run over/under has an equal 50-50 chance of hitting.

Giants vs. Padres odds [8/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Padres
Run Line	+1.5 (-175)	-1.5 (+155)
Moneyline	+120	-134
Total	o8 (-110)	u8 (-108)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Padres picks and best bets

Our model's strongest edge in today's Giants vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Giants vs. Padres game-day updates and essential details

Wednesday's MLB game between the Padres and Giants at PETCO Park is scheduled to start at 9:40PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Wednesday, August 20, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Wednesday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 60% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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