Giants vs. Padres Prediction: San Francisco Predicted to Win Tuesday's MLB Matchup [4/29/2025]

MLB action continues on Tuesday at 9:40PM ET as the San Francisco Giants take on the San Diego Padres at PETCO Park.

The Padres will start Nick Pivetta (4-1, 1.20 ERA), pitting him against Logan Webb (3-1, 1.98 ERA) for the Giants.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's San Francisco-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Giants with a win probability of 52%, compared to 48% for the Padres."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

Padres vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Tuesday's MLB matchup between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Giants a 52% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 64% chance of covering the run line, while the 6.5-run over/under has a 53% chance of going over.

Giants vs. Padres Odds [4/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Padres
Run Line	-1.5 (+150)	+1.5 (-175)
Moneyline	-120	+105
Total	o6.5 (-122)	u6.5 (+105)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Padres Picks and Best Bets

Our model's strongest edge in today's Giants vs. Padres matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. Padres Game-Day Updates and Essential Details

Tuesday's MLB game between the Padres and Giants at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Tuesday, April 29, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Tuesday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Giants, with a 52% win probability, will likely beat the Padres on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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