Giants vs. Padres prediction: San Diego predicted to win Tuesday's MLB matchup [8/19/2025]

MLB action continues on Tuesday at 9:40PM ET as the San Francisco Giants square off with the San Diego Padres at PETCO Park.

The Padres will have Nick Pivetta (12-4, 2.87 ERA) as their starting pitcher, up against Kai-Wei Teng (1-2, 9.90 ERA) for the Giants.

Based on the latest simulation results, Dimers' proven MLB model predicts the Padres as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

Padres vs. Giants prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 65% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 53% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going over.

Giants vs. Padres odds [8/19/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Padres
Run Line	+1.5 (-118)	-1.5 (+101)
Moneyline	+180	-199
Total	o7.5 (-119)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Padres picks and best bets

Our model's strongest edge in today's Giants vs. Padres matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Giants vs. Padres game-day updates and essential details

Tuesday's MLB matchup between the Padres and Giants at PETCO Park is scheduled to start at 9:40PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Tuesday, August 19, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Tuesday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 65% win probability, will likely beat the Giants on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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