Giants vs. Padres prediction: San Diego favored to win Thursday's MLB matchup [8/21/2025]

The San Diego Padres and San Francisco Giants will meet in MLB action at PETCO Park on Thursday, starting at 4:10PM ET.

Dylan Cease (5-11, 4.61 ERA) will start for the Padres, pitting him against Justin Verlander (1-9, 4.23 ERA) for the Giants.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

Padres vs. Giants prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 66% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 54% chance of covering the run line, while the 8-run over/under has a 53% chance of staying under.

Giants vs. Padres odds [8/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Padres
Run Line	+1.5 (-131)	-1.5 (+115)
Moneyline	+162	-190
Total	o8 (-102)	u8 (-119)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Padres picks and best bets

Our model's strongest edge in today's Giants vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Giants vs. Padres game-day updates and essential details

Thursday's MLB game between the Padres and Giants at PETCO Park is scheduled to start at 4:10PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Thursday, August 21, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Thursday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 66% win probability, will likely beat the Giants on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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