Giants vs. Padres prediction: San Diego predicted to win Monday's MLB matchup [8/18/2025]

The San Diego Padres will face the San Francisco Giants in MLB action at PETCO Park on Monday, commencing at 9:40PM ET.

Nestor Cortes (1-1, 5.71 ERA) will get the ball for the Padres, pitting him against Robbie Ray (9-6, 2.98 ERA) for the Giants.

Based on the latest simulations, Dimers' proven MLB model predicts the Padres as the most likely winner of today's game.

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Giants vs. Padres predictions page.

Padres vs. Giants prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Monday's MLB matchup between the Giants and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 61% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Giants vs. Padres odds [8/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Padres
Run Line	+1.5 (-175)	-1.5 (+146)
Moneyline	+130	-142
Total	o7.5 (-110)	u7.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Padres picks and best bets

Our model's strongest edge in today's Giants vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Giants vs. Padres game-day updates and essential details

Monday's MLB game between the Padres and Giants at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Monday, August 18, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Monday's Giants vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 61% win probability, will likely beat the Giants on Monday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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