Giants vs. Phillies Prediction: Philadelphia Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The Philadelphia Phillies will square off with the San Francisco Giants in MLB action at Citizens Bank Park on Wednesday, commencing at 6:45PM ET.

The Phillies will send Aaron Nola (0-3, 5.51 ERA) to the mound, up against Robbie Ray (3-0, 2.94 ERA) for the Giants.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Francisco-Philadelphia game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 57%, with the Giants at 43%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Phillies predictions page.

Giants vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Giants and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 57% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 51% chance of staying under.

Giants vs. Phillies Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Phillies
Run Line	+1.5 (-162)	-1.5 (+154)
Moneyline	+130	-145
Total	o8 (-110)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Phillies Picks and Best Bets

Our model's biggest edge in today's Giants vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Giants vs. Phillies Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Phillies and Giants at Citizens Bank Park is scheduled to begin at 6:45PM ET.

• Who: San Francisco Giants vs. Philadelphia Phillies
• Date: Wednesday, April 16, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers.com's full preview of Wednesday's Giants vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Philadelphia picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Phillies, with a 57% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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