Giants vs. Brewers prediction: Why Milwaukee is favored to win Friday's MLB matchup [8/22/2025]

MLB action continues on Friday at 8:10PM ET as the San Francisco Giants square off with the Milwaukee Brewers at American Family Field.

Jose Quintana (10-4, 3.32 ERA) will get the ball for the Brewers, pitting him against Carson Whisenhunt (1-1, 5.02 ERA) for the Giants.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Brewers as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Giants vs. Brewers predictions page.

Brewers vs. Giants prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Giants and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 60% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 59% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Giants vs. Brewers odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Brewers
Run Line	+1.5 (-130)	-1.5 (+110)
Moneyline	+155	-184
Total	o9 (-104)	u9 (-116)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Brewers picks and best bets

Our model's strongest edge in today's Giants vs. Brewers matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Giants vs. Brewers game-day updates and essential details

Friday's MLB matchup between the Brewers and Giants at American Family Field is scheduled to start at 8:10PM ET.

• Who: San Francisco Giants vs. Milwaukee Brewers
• Date: Friday, August 22, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: American Family Field

Dimers.com's in-depth preview of Friday's Giants vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 60% win probability, will likely beat the Giants on Friday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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