Giants vs. Dodgers prediction: Cy Young candidate Yoshinobu Yamamoto takes on San Francisco tonight [9/18/2025]

The Los Angeles Dodgers and San Francisco Giants will meet in MLB action at Dodger Stadium on Thursday, starting at 10:10PM ET.

The Dodgers will start Cy Young fancy Yoshinobu Yamamoto (11-8, 2.66 ERA), pitting him against fellow hopeful Logan Webb (14-10, 3.34 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model projects the Dodgers as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Giants vs. Dodgers predictions page.

Dodgers vs. Giants prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Thursday's MLB matchup between the Giants and Dodgers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Dodgers a 62% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 58% chance of covering the run line, while the 7.5-run over/under has a 55% chance of going over.

Giants vs. Dodgers odds [9/18/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Dodgers
Run Line	+1.5 (-152)	-1.5 (+135)
Moneyline	+145	-172
Total	o7.5 (-104)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Dodgers picks and best bets

Our model's biggest edge in today's Giants vs. Dodgers matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. Dodgers game-day updates and essential details

Thursday's MLB action between the Dodgers and Giants at Dodger Stadium is scheduled to begin at 10:10PM ET.

• Who: San Francisco Giants vs. Los Angeles Dodgers
• Date: Thursday, September 18, 2025
• Time: 10:10PM ET/7:10PM PT
• Venue: Dodger Stadium

Dimers' in-depth preview of Thursday's Giants vs. Dodgers matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Dodgers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Thursday

To make the most of Thursday's big day of sports, headlined by the Dolphins-Bills TNF clash, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Dodgers, with a 62% win probability, will likely beat the Giants on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Dodgers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most accurate predictions for the World Series, American League, National League and each division.