Giants vs. Dodgers prediction: Dodgers favored to win Sunday's MLB matchup [9/21/2025]

MLB action continues on Sunday at 4:10PM ET as the San Francisco Giants take on the favored Los Angeles Dodgers at Dodger Stadium.

Emmet Sheehan (6-3, 3.17 ERA) will be the starting pitcher for the Dodgers, pitting him against Trevor McDonald (0-0, 9.00 ERA) for the Giants.

Based on the latest simulations, Dimers' proven MLB model predicts the Dodgers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Giants-Dodgers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Dodgers with a win probability of 66%, while the Giants have 34%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Giants vs. Dodgers predictions page.

Dodgers vs. Giants prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Giants and Dodgers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Dodgers a 66% chance of defeating the Giants.

According to our model, the bookmakers have got it right, and the Giants and Dodgers each have a 50% chance of covering the run line, while the 9-run over/under has a 55% chance of going over.

Giants vs. Dodgers odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Dodgers
Run Line	+1.5 (-111)	-1.5 (-102)
Moneyline	+184	-210
Total	o9 (-118)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Dodgers picks and best bets

Our model's strongest edge in today's Giants vs. Dodgers matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Giants vs. Dodgers game-day updates and essential details

Sunday's MLB matchup between the Dodgers and Giants at Dodger Stadium is scheduled to commence at 4:10PM ET.

• Who: San Francisco Giants vs. Los Angeles Dodgers
• Date: Sunday, September 21, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Dodger Stadium

Dimers' full preview of Sunday's Giants vs. Dodgers matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Dodgers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Dodgers, with a 66% win probability, will likely beat the Giants on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Dodgers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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