Giants vs. Dodgers prediction: Dodgers favored to win Saturday's MLB matchup [9/20/2025]

The Los Angeles Dodgers will face the San Francisco Giants in MLB action at Dodger Stadium on Saturday, beginning at 9:10PM ET.

The Dodgers will send Tyler Glasnow (3-3, 3.06 ERA) to the mound, pitting him against Kai-Wei Teng (2-4, 6.41 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model projects the Dodgers as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Giants vs. Dodgers predictions page.

Dodgers vs. Giants prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB game between the Giants and Dodgers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Dodgers a 68% chance of defeating the Giants.

According to our model, the Dodgers (-1.5) have a 51% chance of covering the run line, while the 8.5-run over/under has a 55% chance of going over.

Giants vs. Dodgers odds [9/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Dodgers
Run Line	+1.5 (+100)	-1.5 (-115)
Moneyline	+201	-235
Total	o8.5 (-120)	u8.5 (+104)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Dodgers picks and best bets

Our model's biggest edge in today's Giants vs. Dodgers matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. Dodgers game-day updates and essential details

Saturday's MLB action between the Dodgers and Giants at Dodger Stadium is scheduled to start at 9:10PM ET.

• Who: San Francisco Giants vs. Los Angeles Dodgers
• Date: Saturday, September 20, 2025
• Time: 9:10PM ET/6:10PM PT
• Venue: Dodger Stadium

Dimers' comprehensive preview of Saturday's Giants vs. Dodgers matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Dodgers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Dodgers, with a 68% win probability, will likely beat the Giants on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Dodgers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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