Giants vs. Tigers Prediction: Detroit Predicted to Win Wednesday's MLB Matchup [5/28/2025]

The Detroit Tigers and San Francisco Giants will meet in MLB action at Comerica Park on Wednesday, starting at 1:10PM ET.

Jackson Jobe (4-1, 4.06 ERA) will start for the Tigers, pitting him against Landen Roupp (3-3, 3.64 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Francisco-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Tigers' chance of winning at 52%, with the Giants at 48%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Tigers predictions page.

Tigers vs. Giants Prediction: Who Will Win?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Giants and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Tigers a 52% chance of defeating the Giants.

According to our model, the 7.5-run over/under has a 53% chance of going over.

Giants vs. Tigers Odds [5/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Tigers
Moneyline	+100	-112
Total	o7.5 (-120)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Tigers Picks and Best Bets

Our model's strongest edge in today's Giants vs. Tigers matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

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Giants vs. Tigers Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Tigers and Giants at Comerica Park is scheduled to commence at 1:10PM ET.

• Who: San Francisco Giants vs. Detroit Tigers
• Date: Wednesday, May 28, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Wednesday's Giants vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 52% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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