Giants vs. Tigers Prediction: Detroit Predicted to Win Monday's MLB Matchup [5/26/2025]

The Detroit Tigers will take on the San Francisco Giants, in what is expected to be a close MLB game, at Comerica Park on Monday, commencing at 1:10PM ET.

Keider Montero (1-1, 5.28 ERA) will be on the bump for the Tigers, pitting him against Hayden Birdsong (2-0, 1.91 ERA) for the Giants.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's San Francisco-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Tigers are likely to win, with a probability of 51%, compared to the Giants' 49%."

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Giants vs. Tigers predictions page.

Tigers vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Monday's MLB game between the Giants and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Tigers a 51% chance of beating the Giants.

According to our model, the Tigers (+1.5) have a 64% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Giants vs. Tigers Odds [5/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Tigers
Run Line	-1.5 (+164)	+1.5 (-190)
Moneyline	-102	-110
Total	o8.5 (-105)	u8.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Tigers Picks and Best Bets

Our model's strongest edge in today's Giants vs. Tigers matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Giants vs. Tigers Game-Day Updates and Essential Details

Monday's MLB matchup between the Tigers and Giants at Comerica Park is scheduled to start at 1:10PM ET.

• Who: San Francisco Giants vs. Detroit Tigers
• Date: Monday, May 26, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Monday's Giants vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 51% win probability, will likely beat the Giants on Monday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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