Giants vs. Rockies prediction: Why San Francisco is favored to win Wednesday's MLB matchup [9/3/2025]

The Colorado Rockies and San Francisco Giants are scheduled to meet in MLB action at Coors Field on Wednesday, starting at 8:40PM ET.

The Rockies will start Germán Márquez (3-12, 6.14 ERA), while the Giants have opted for Robbie Ray (10-6, 3.18 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Giants as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Giants-Rockies game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Giants' chance of winning at 59%, with the Rockies at 41%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Rockies predictions page.

Rockies vs. Giants prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Giants and Rockies 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Giants a 59% chance of defeating the Rockies.

According to our model, the Rockies (+1.5) have a 51% chance of covering the run line, while the over/under total of 11.5 runs has a 53% chance of staying under.

Giants vs. Rockies odds [9/3/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Rockies
Run Line	-1.5 (-122)	+1.5 (+105)
Moneyline	-180	+155
Total	o11.5 (-105)	u11.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Rockies picks and best bets

Our model's strongest edge in today's Giants vs. Rockies matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. Rockies game-day updates and essential details

Wednesday's MLB action between the Rockies and Giants at Coors Field is scheduled to start at 8:40PM ET.

• Who: San Francisco Giants vs. Colorado Rockies
• Date: Wednesday, September 3, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: Coors Field

Dimers.com's full preview of Wednesday's Giants vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Rockies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Giants, with a 59% win probability, will likely beat the Rockies on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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