Giants vs. White Sox Prediction: San Francisco Predicted to Win Saturday's MLB Matchup [6/28/2025]

The Chicago White Sox and San Francisco Giants are scheduled to meet in MLB action at Rate Field on Saturday, starting at 4:10PM ET.

Adrian Houser (2-2, 2.27 ERA) will start on the mound for the White Sox, up against Robbie Ray (8-2, 2.83 ERA) for the Giants.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Giants as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Giants-White Sox game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Giants are more likely to win, while the White Sox have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Giants vs. White Sox predictions page.

White Sox vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Giants and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Giants a 61% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 54% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.

Giants vs. White Sox Odds [6/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	White Sox
Run Line	-1.5 (+105)	+1.5 (-120)
Moneyline	-166	+140
Total	o7.5 (-115)	u7.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Giants vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Giants vs. White Sox matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. White Sox Game-Day Updates and Essential Details

Saturday's MLB game between the White Sox and Giants at Rate Field is scheduled to begin at 4:10PM ET.

• Who: San Francisco Giants vs. Chicago White Sox
• Date: Saturday, June 28, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Rate Field

Dimers.com's full preview of Saturday's Giants vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Giants, with a 61% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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