Giants vs. White Sox Prediction: San Francisco Predicted to Win Friday's MLB Matchup [6/27/2025]

MLB action continues on Friday at 7:40PM ET as the San Francisco Giants take on the Chicago White Sox at Rate Field.

The White Sox will start Aaron Civale (1-4, 5.03 ERA), while the Giants are going with Landen Roupp (5-5, 3.67 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Giants-White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Giants' chance of winning is 60%, while the White Sox' is 40%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Giants vs. White Sox predictions page.

White Sox vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Giants and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Giants a 60% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 54% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of staying under.

Giants vs. White Sox Odds [6/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	White Sox
Run Line	-1.5 (+105)	+1.5 (-125)
Moneyline	-158	+135
Total	o9 (-115)	u9 (-104)

All odds are correct at the time of publication and are subject to change.

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Giants vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Giants vs. White Sox matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. White Sox Game-Day Updates and Essential Details

Friday's MLB game between the White Sox and Giants at Rate Field is scheduled to begin at 7:40PM ET.

• Who: San Francisco Giants vs. Chicago White Sox
• Date: Friday, June 27, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's full preview of Friday's Giants vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Giants, with a 60% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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