Giants vs. Cubs Prediction: Cubs Predicted to Win Tuesday's MLB Matchup [5/6/2025]

MLB action continues on Tuesday at 7:40PM ET as the San Francisco Giants square off with the Chicago Cubs at Wrigley Field.

The Cubs will send Colin Rea (2-0, 1.46 ERA) to the mound, while the Giants have opted for Justin Verlander (0-2, 4.38 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's San Francisco-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Cubs with a win probability of 58%, compared to 42% for the Giants."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Giants vs. Cubs predictions page.

Cubs vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Giants and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 58% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of staying under.

Giants vs. Cubs Odds [5/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Cubs
Run Line	+1.5 (-160)	-1.5 (+142)
Moneyline	+126	-148
Total	o8.5 (-102)	u8.5 (-118)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Giants vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Giants vs. Cubs matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Giants vs. Cubs Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Cubs and Giants at Wrigley Field is scheduled to begin at 7:40PM ET.

• Who: San Francisco Giants vs. Chicago Cubs
• Date: Tuesday, May 6, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Tuesday's Giants vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cubs, with a 58% win probability, will likely beat the Giants on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate probabilities for the World Series, American League, National League and each division.