Giants vs. Cubs Prediction: Cubs Predicted to Win Monday's MLB Matchup [5/5/2025]

MLB action continues on Monday at 7:40PM ET as the San Francisco Giants square off with the Chicago Cubs at Wrigley Field.

Matthew Boyd (2-2, 2.70 ERA) will start for the Cubs, up against Landen Roupp (2-2, 5.10 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's San Francisco-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Cubs are likely to win, with a probability of 57%, compared to the Giants' 43%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Giants vs. Cubs predictions page.

Cubs vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Giants and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 57% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 62% chance of covering the run line, while the over/under total of 7 runs has a 52% chance of going over.

Giants vs. Cubs Odds [5/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Cubs
Run Line	+1.5 (-148)	-1.5 (+126)
Moneyline	+150	-172
Total	o7 (-125)	u7 (+105)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Giants vs. Cubs matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Giants vs. Cubs Game-Day Updates and Essential Details

Monday's MLB matchup between the Cubs and Giants at Wrigley Field is scheduled to begin at 7:40PM ET.

• Who: San Francisco Giants vs. Chicago Cubs
• Date: Monday, May 5, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Wrigley Field

Dimers.com's full preview of Monday's Giants vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Giants on Monday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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