Giants vs. Diamondbacks prediction: Tight battle projected in updated analysis for Wednesday's MLB matchup [9/17/2025]

MLB action continues on Wednesday at 3:40PM ET as the San Francisco Giants square off with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will have Brandon Pfaadt (13-8, 5.31 ERA) as their starting pitcher, up against Justin Verlander (3-10, 3.94 ERA) for the Giants.

Based on the latest simulation results, Dimers' advanced MLB model projects an equal chance for both the Diamondbacks and Giants to win today's game.

"Our team has simulated the outcome of Wednesday's Giants-Diamondbacks game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Diamondbacks and Giants, making it a highly competitive matchup."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Diamondbacks predictions page.

Diamondbacks vs. Giants prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Giants and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently can't split the two teams, giving both the Giants and Diamondbacks a 50% chance of winning the game.

According to our model, the Diamondbacks (+1.5) have a 62% chance of covering the run line, while the 9-run over/under has a 53% chance of going over.

Giants vs. Diamondbacks odds [9/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Diamondbacks
Run Line	-1.5 (+150)	+1.5 (-176)
Moneyline	-108	-108
Total	o9 (-105)	u9 (-112)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Giants vs. Diamondbacks matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Giants vs. Diamondbacks game-day updates and essential details

Wednesday's MLB action between the Diamondbacks and Giants at Chase Field is scheduled to commence at 3:40PM ET.

• Who: San Francisco Giants vs. Arizona Diamondbacks
• Date: Wednesday, September 17, 2025
• Time: 3:40PM ET/12:40PM PT
• Venue: Chase Field

Dimers' comprehensive preview of Wednesday's Giants vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Giants and Diamondbacks on Wednesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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