Giants vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [9/16/2025]

The Arizona Diamondbacks will face the San Francisco Giants in MLB action at Chase Field on Tuesday, starting at 9:40PM ET.

The Diamondbacks will start Eduardo Rodriguez (8-8, 4.98 ERA), up against Tristan Beck (1-0, 4.88 ERA) for the Giants.

Based on the latest simulations, Dimers' proven MLB model predicts the Diamondbacks as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Giants vs. Diamondbacks predictions page.

Diamondbacks vs. Giants prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB game between the Giants and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Diamondbacks a 56% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 61% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of going over.

Giants vs. Diamondbacks odds [9/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Diamondbacks
Run Line	+1.5 (-187)	-1.5 (+165)
Moneyline	+113	-125
Total	o9 (-115)	u9 (-105)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Diamondbacks picks and best bets

Our model's biggest edge in today's Giants vs. Diamondbacks matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Giants vs. Diamondbacks game-day updates and essential details

Tuesday's MLB action between the Diamondbacks and Giants at Chase Field is scheduled to commence at 9:40PM ET.

• Who: San Francisco Giants vs. Arizona Diamondbacks
• Date: Tuesday, September 16, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers' full preview of Tuesday's Giants vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Giants vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Diamondbacks, with a 56% win probability, will likely beat the Giants on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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