San Francisco 49ers vs. Seattle Seahawks updated prediction featuring Christian McCaffrey, Kenneth Walker [Week 1, 2025]

Dimers' latest NFL predictions are live for Seattle Seahawks and San Francisco 49ers in Week 1, with our model giving the 49ers a 59% of winning against the Seahawks on Sunday.

This update builds on our early Seahawks-49ers predictions, delivering renewed win probabilities, score projections, and TD predictions for Christian McCaffrey, Kenneth Walker, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our 49ers vs. Seahawks page.

What's changed? San Francisco vs. Seattle updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Niners vs. Seahawks matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: 49ers 59%, Seahawks 41%
• Predicted Final Score: 49ers 22-19 Seahawks
• Spread: 49ers (-1.5) 53%, Seahawks (+1.5) 47%
• Total Points (43.5): Over 44%, Under 56%

As of September 5, 2025, these 49ers-Seahawks calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Niners-Seahawks on Sunday:

San Francisco 49ers

• Christian McCaffrey: 51.5% probability
• George Kittle: 34.7% probability
• Ricky Pearsall: 30.8% probability

Seattle Seahawks

• Kenneth Walker: 44.4% probability
• Jaxon Smith-Njigba: 34.2% probability
• Zach Charbonnet: 30.3% probability

Niners vs. Seahawks latest odds

The best current odds from the top sportsbooks in the US:

• Spread: 49ers -1.5 (-110), Seahawks +1.5 (-105)
• Moneyline: 49ers -126, Seahawks +110
• Total: Over/Under 43.5 (-104/-112)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Niners vs. Seahawks Week 1 details

The NFL Week 1 matchup between the Seahawks and 49ers at Lumen Field is scheduled for September 7, 2025.

• Who: San Francisco 49ers vs. Seattle Seahawks
• Date: Sunday, September 7, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Seahawks in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Seahawks game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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