49ers vs. Seahawks prediction: San Francisco favored to win in NFL Week 1, 2025

The Seattle Seahawks will face the San Francisco 49ers in NFL Week 1 action at Lumen Field on Sunday, starting at 4:05PM ET.

Based on the latest simulation results, Dimers' proven NFL model projects the 49ers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's 49ers-Seahawks game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 59%, while the Seahawks have 41%."

This updated 49ers vs. Seahawks betting preview builds on my 49ers vs. Seahawks prediction that was published earlier in the week.

For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Seahawks predictions page.

49ers vs. Seahawks Predictions

Since our 49ers-Seahawks predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the 49ers and Seahawks 10,000 times as part of our NFL predictions coverage.

Our leading predictive model gives the 49ers a 59% chance of defeating the Seahawks in Week 1 of the NFL season. Our predicted final score has the 49ers winning 22-19.

According to our model, the 49ers (-1.5) have a 53% chance of covering the spread, while the 43.5-point over/under has a 56% chance of staying under.

49ers vs. Seahawks odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	49ers	Seahawks
Spread	-1.5 (-110)	+1.5 (-102)
Moneyline	-125	+114
Total	o43.5 (-104)	u43.5 (-110)

All odds are correct at the time of publication and are subject to change.

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49ers vs. Seahawks picks and best bets

Our model's strongest edge in today's 49ers vs. Seahawks matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season, with today's best NFL bets populating now.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

49ers vs. Seahawks TD scorers

Who will score the first touchdown in 49ers vs. Seahawks?

According to our list of touchdown scorer predictions for Week 1, San Francisco's Christian McCaffrey is most likely to score the first TD in 49ers vs. Seahawks.

Our projections give McCaffrey a 13.8% chance of scoring the first TD at Lumen Field, while the 49ers running back is a 49.0% chance of scoring an anytime touchdown.

First touchdown scorer predictions

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	13.8%
George Kittle (TE)	8.3%
Ricky Pearsall (WR)	6.4%

Seattle Seahawks

Player	First TD Probability
Kenneth Walker (RB)	10.4%
Jaxon Smith-Njigba (WR)	7.8%
Zach Charbonnet (RB)	6.7%

Anytime touchdown scorer predictions

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	49.0%
George Kittle (TE)	33.3%
Ricky Pearsall (WR)	26.8%

Seattle Seahawks

Player	Anytime TD Probability
Kenneth Walker (RB)	42.5%
Jaxon Smith-Njigba (WR)	33.8%
Zach Charbonnet (RB)	29.9%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 1 touchdown scorer predictions

49ers vs Seahawks player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Seahawks. For more, check out today's highest-probability NFL prop bets.

Already a Dimers Pro member? Head to our 49ers-Seahawks page now to access every player prop projection.

49ers vs. Seahawks quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected to throw for more yards than the Seahawks' Sam Darnold.

49ers rushing

Christian McCaffrey, Brian Robinson and Brock Purdy are projected to be the leading rushers for the 49ers.

Player	Position
Christian McCaffrey	RB
Brian Robinson	RB
Brock Purdy	QB

Seahawks rushing

Kenneth Walker, Zach Charbonnet and Sam Darnold are expected to lead the Seahawks in rushing yards.

Player	Position
Kenneth Walker	RB
Zach Charbonnet	RB
Sam Darnold	QB

49ers receiving

George Kittle, Jauan Jennings, Ricky Pearsall, Christian McCaffrey and Russell Gage are projected to top the receiving yards for the 49ers.

Player	Position
George Kittle	TE
Jauan Jennings	WR
Ricky Pearsall	WR
Christian McCaffrey	RB
Russell Gage	WR

Seahawks receiving

Jaxon Smith-Njigba, Cooper Kupp, Tory Horton, AJ Barner and Kenneth Walker are projected to lead the Seahawks in receiving yards.

Player	Position
Jaxon Smith-Njigba	WR
Cooper Kupp	WR
Tory Horton	WR
AJ Barner	TE
Kenneth Walker	RB

Niners vs. Seahawks game-day updates and essential details

The NFL Week 1 action between the Seahawks and 49ers at Lumen Field is scheduled to begin at 4:05PM ET.

• Who: San Francisco 49ers vs. Seattle Seahawks
• Date: Sunday, September 7, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

Dimers.com's comprehensive preview of this week's 49ers vs. Seahawks matchup includes our prediction, picks and the latest betting odds.

Before making any Niners vs. Seahawks picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Seahawks in Week 1 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Seahawks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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