San Francisco 49ers vs. Seattle Seahawks early prediction: Expert picks for NFL Week 1, 2025

The San Francisco 49ers and Seattle Seahawks will meet in Week 1 of the NFL season at Lumen Field on Sunday, September 7, 2025, starting at 4:05PM ET.

Early simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Seahawks predictions page.

San Francisco vs. Seattle early predictions

Leveraging trusted machine learning and analysis, we have simulated the Niners vs. Seahawks game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: 49ers 58%, Seahawks 42%
• Predicted final score: 49ers 23-21 Seahawks
• Spread: 49ers (-2.5) 50%, Seahawks (+2.5) 50%
• Total points (44.5): Over 50%, Under 50%

As of August 31, 2025, these 49ers-Seahawks calculations and predictions reflect the latest data and insights available.

Niners vs. Seahawks Week 1 details

The NFL Week 1 matchup between the Seahawks and 49ers at Lumen Field is scheduled for September 7, 2025.

• Who: San Francisco 49ers vs. Seattle Seahawks
• Date: Sunday, September 7, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

Niners vs. Seahawks opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: 49ers -2.5 (-110), Seahawks +2.5 (-110)
• Moneyline: 49ers -135, Seahawks +116
• Total: Over/Under 44.5 (-102/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the 49ers, with a 58% win probability, will likely beat the Seahawks in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Seahawks matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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