San Francisco 49ers vs. New Orleans Saints updated prediction featuring Christian McCaffrey, Alvin Kamara [Week 2, 2025]

Dimers' latest NFL predictions are live for New Orleans Saints and San Francisco 49ers in Week 2, with our model giving the 49ers a 64% of winning against the Saints on Sunday.

This update builds on our early Saints-49ers predictions, providing fresh win probabilities, score projections, and TD predictions for Christian McCaffrey, Alvin Kamara, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our 49ers vs. Saints page.

What's changed? San Francisco vs. New Orleans updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Niners vs. Saints matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: 49ers 64%, Saints 36%
• Predicted Final Score: 49ers 21-18 Saints
• Spread: 49ers (-3) 50%, Saints (+3) 50%
• Total Points (40.5): Over 50%, Under 50%

As of September 11, 2025, these 49ers-Saints figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Niners-Saints on Sunday:

San Francisco 49ers

• Christian McCaffrey: 49.0% probability
• Ricky Pearsall: 27.3% probability
• Brian Robinson: 26.4% probability

New Orleans Saints

• Alvin Kamara: 42.9% probability
• Rashid Shaheed: 28.4% probability
• Juwan Johnson: 22.1% probability

Niners vs. Saints latest odds

The best current odds from the top sportsbooks in the US:

• Spread: 49ers -3 (-110), Saints +3 (-105)
• Moneyline: 49ers -162, Saints +142
• Total: Over/Under 40.5 (-105/-108)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Niners vs. Saints Week 2 details

The NFL Week 2 matchup between the Saints and 49ers at Caesars Superdome is scheduled for September 14, 2025.

• Who: San Francisco 49ers vs. New Orleans Saints
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

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Conclusion

We predict the 49ers, with a 64% win probability, will likely beat the Saints in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Saints matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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