49ers vs. Saints prediction: San Francisco favored to win in NFL Week 2, 2025

NFL Week 2 action continues on Sunday at 1:00PM ET as the San Francisco 49ers square off with the New Orleans Saints at Caesars Superdome.

Based on updated simulation results, Dimers' proven NFL model projects the 49ers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's 49ers-Saints game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 64%, while the Saints have 36%."

This gameday 49ers vs. Saints betting preview builds on my 49ers vs. Saints prediction that was released earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Saints predictions page.

49ers vs. Saints Predictions

Since our 49ers-Saints predictions earlier in the week, we have simulated the result of Sunday's NFL game between the 49ers and Saints 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the 49ers a 64% chance of beating the Saints in Week 2 of the NFL season. Our predicted final score has the 49ers winning 21-18.

According to our model, the bookmakers have got it right, and the 49ers and Saints each have a 50% chance of covering the spread, while the 40.5-point over/under also has an equal 50-50 chance of hitting.

49ers vs. Saints odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	49ers	Saints
Spread	-3 (-104)	+3 (-110)
Moneyline	-154	+140
Total	o40.5 (-106)	u40.5 (-105)

All odds are correct at the time of publication and are subject to change.

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49ers vs. Saints picks and best bets

Our model's biggest edge in today's 49ers vs. Saints matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

49ers vs. Saints TD scorers

Who will score the first touchdown in 49ers vs. Saints?

According to our model, San Francisco's Christian McCaffrey is most likely to score the first TD in 49ers vs. Saints.

Our projections give McCaffrey a 16.7% chance of scoring the first TD at Caesars Superdome, while the 49ers running back is a 52.9% chance of reaching the end zone at any point during the game.

First touchdown scorer predictions

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	16.7%
Ricky Pearsall (WR)	6.9%
Jauan Jennings (WR)	6.0%

New Orleans Saints

Player	First TD Probability
Alvin Kamara (RB)	14.0%
Chris Olave (WR)	6.8%
Rashid Shaheed (WR)	6.2%

Anytime touchdown scorer predictions

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	52.9%
Ricky Pearsall (WR)	26.6%
Jauan Jennings (WR)	23.7%

New Orleans Saints

Player	Anytime TD Probability
Alvin Kamara (RB)	44.5%
Chris Olave (WR)	24.9%
Rashid Shaheed (WR)	23.1%

49ers vs Saints player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Saints. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our 49ers-Saints page now to access every player prop projection.

49ers vs. Saints quarterbacks

Of the starting quarterbacks, the 49ers' Mac Jones is projected to throw for fewer yards than the Saints' Spencer Rattler.

49ers rushing

Christian McCaffrey, Brian Robinson and Mac Jones are projected to be the leading rushers for the 49ers.

Player	Position
Christian McCaffrey	RB
Brian Robinson	RB
Mac Jones	QB

Saints rushing

Alvin Kamara, Spencer Rattler and Kendre Miller are expected to lead the Saints in rushing yards.

Player	Position
Alvin Kamara	RB
Spencer Rattler	QB
Kendre Miller	RB

49ers receiving

Ricky Pearsall, Jauan Jennings, Christian McCaffrey, Jake Tonges and Luke Farrell are projected to top the receiving yards for the 49ers.

Player	Position
Ricky Pearsall	WR
Jauan Jennings	WR
Christian McCaffrey	RB
Jake Tonges	TE
Luke Farrell	TE

Saints receiving

Chris Olave, Rashid Shaheed, Juwan Johnson, Alvin Kamara and Brandin Cooks are projected to lead the Saints in receiving yards.

Player	Position
Chris Olave	WR
Rashid Shaheed	WR
Juwan Johnson	TE
Alvin Kamara	RB
Brandin Cooks	WR

Niners vs. Saints game-day updates and essential details

The NFL Week 2 matchup between the Saints and 49ers at Caesars Superdome is scheduled to start at 1:00PM ET.

• Who: San Francisco 49ers vs. New Orleans Saints
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

Dimers' comprehensive preview of Sunday's 49ers vs. Saints matchup includes our prediction, picks and the latest betting odds.

Before making any Niners vs. Saints picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the 49ers, with a 64% win probability, will likely beat the Saints in Week 2 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Saints insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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