San Francisco 49ers vs. Los Angeles Rams early prediction: Expert picks for NFL Week 5, 2025

The San Francisco 49ers and Los Angeles Rams will meet in Week 5 of the NFL season at SoFi Stadium on Thursday, October 2, 2025, starting at 8:15PM ET.

Initial simulations from Dimers' trusted NFL model favor the Rams as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Rams predictions page.

San Francisco vs. LA Rams early predictions

Leveraging trusted machine learning and analysis, we have simulated the Niners vs. Rams game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: 49ers 46%, Rams 54%
• Predicted final score: 49ers 22-23 Rams
• Spread: 49ers (+1.5) 50%, Rams (-1.5) 50%
• Total points (47.5): Over 46%, Under 54%

As of September 28, 2025, these 49ers-Rams numbers and predictions reflect the latest data and insights available.

Niners vs. Rams Week 5 details

The NFL Week 5 action between the Rams and 49ers at SoFi Stadium is scheduled for October 2, 2025.

• Who: San Francisco 49ers vs. Los Angeles Rams
• Date: Thursday, October 2, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: SoFi Stadium

Niners vs. Rams opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: 49ers +1.5 (-110), Rams -1.5 (-110)
• Moneyline: 49ers +105, Rams -120
• Total: Over/Under 47.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Rams, with a 54% win probability, will likely beat the 49ers in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Rams game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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