San Diego State vs. Northern Illinois prediction: Northern Illinois favored to win in college football Week 5, 2025

Northern Illinois and San Diego State will clash in Week 5 college football action at Brigham Field at Huskie Stadium on Saturday, commencing at 3:30PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Northern Illinois as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive San Diego State vs. Northern Illinois predictions page.

San Diego State vs. Northern Illinois prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of San Diego State vs. Northern Illinois 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Northern Illinois a 57% chance of beating San Diego State. Our predicted final score has Northern Illinois winning 23-20.

According to our model, Northern Illinois (+1.5) has a 57% chance of covering the spread, while the 41.5-point over/under has a 54% chance of staying under.

San Diego State vs. Northern Illinois odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	San Diego State	Northern Illinois
Spread	-1.5 (-110)	+1.5 (-110)
Moneyline	-115	+105
Total	o41.5 (-115)	u41.5 (-105)

All odds are correct at the time of publication and are subject to change.

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San Diego State vs. Northern Illinois picks and best bets

Our model's biggest edge in today's San Diego State vs. Northern Illinois matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

San Diego State vs. Northern Illinois game-day updates and essential details

Saturday's college football matchup between Northern Illinois and San Diego State at Brigham Field at Huskie Stadium is scheduled to commence at 3:30PM ET.

• Who: San Diego State vs. Northern Illinois
• Date: Saturday, September 27, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Brigham Field at Huskie Stadium

Dimers' comprehensive preview of Saturday's San Diego State vs. Northern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego State vs. Northern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Northern Illinois, with a 57% win probability, will likely beat San Diego State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate San Diego State vs. Northern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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