Padres vs. Nationals Prediction: San Diego Predicted to Win Friday's MLB Matchup [7/18/2025]

The Washington Nationals will take on the San Diego Padres in MLB action at Nationals Park on Friday, commencing at 6:45PM ET.

Michael Soroka (3-7, 5.35 ERA) will be on the bump for the Nationals, while the Padres will counter with Dylan Cease (3-9, 4.88 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Padres vs. Nationals predictions page.

Nationals vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Padres and Nationals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 55% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 58% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Padres vs. Nationals Odds [7/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Nationals
Run Line	-1.5 (+114)	+1.5 (-127)
Moneyline	-146	+127
Total	o8.5 (-110)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Nationals Picks and Best Bets

Our model's biggest edge in today's Padres vs. Nationals matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Padres vs. Nationals Game-Day Updates and Essential Details

Friday's MLB game between the Nationals and Padres at Nationals Park is scheduled to start at 6:45PM ET.

• Who: San Diego Padres vs. Washington Nationals
• Date: Friday, July 18, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Friday's Padres vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 55% win probability, will likely beat the Nationals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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