Padres vs. Blue Jays Prediction: Toronto Predicted to Win Wednesday's MLB Matchup [5/21/2025]

The Toronto Blue Jays will face the San Diego Padres in MLB action at Rogers Centre on Wednesday, commencing at 7:07PM ET.

The Blue Jays will start Kevin Gausman (3-4, 4.59 ERA), while the Padres will counter with Randy Vásquez (3-3, 3.45 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Blue Jays as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Diego-Toronto game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Blue Jays' chance of winning at 58%, with the Padres at 42%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Blue Jays predictions page.

Blue Jays vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Padres and Blue Jays 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Blue Jays a 58% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 60% chance of covering the run line, while the 9-run over/under has a 51% chance of staying under.

Padres vs. Blue Jays Odds [5/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Blue Jays
Run Line	+1.5 (-144)	-1.5 (+125)
Moneyline	+140	-162
Total	o9 (+100)	u9 (-122)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Blue Jays Picks and Best Bets

Our model's strongest edge in today's Padres vs. Blue Jays matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Blue Jays Game-Day Updates and Essential Details

Wednesday's MLB game between the Blue Jays and Padres at Rogers Centre is scheduled to commence at 7:07PM ET.

• Who: San Diego Padres vs. Toronto Blue Jays
• Date: Wednesday, May 21, 2025
• Time: 7:07PM ET/4:07PM PT
• Venue: Rogers Centre

Dimers.com's in-depth preview of Wednesday's Padres vs. Blue Jays matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Toronto picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Blue Jays, with a 58% win probability, will likely beat the Padres on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Blue Jays insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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