Padres vs. Blue Jays Prediction: San Diego Predicted to Win Thursday's MLB Matchup [5/22/2025]

The Toronto Blue Jays will face the San Diego Padres in MLB action at Rogers Centre on Thursday, starting at 1:07PM ET.

Bowden Francis (2-6, 5.63 ERA) will start on the mound for the Blue Jays, up against Stephen Kolek (2-1, 2.33 ERA) for the Padres.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's San Diego-Toronto game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Padres with a win probability of 51% and the Blue Jays with 49%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Padres vs. Blue Jays predictions page.

Blue Jays vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Thursday's MLB game between the Padres and Blue Jays 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 51% chance of defeating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 61% chance of covering the run line, while the over/under total of 9 runs has an equal 50-50 chance of hitting.

Padres vs. Blue Jays Odds [5/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Blue Jays
Run Line	-1.5 (+146)	+1.5 (-166)
Moneyline	-116	+100
Total	o9 (+105)	u9 (-125)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Blue Jays Picks and Best Bets

Our model's biggest edge in today's Padres vs. Blue Jays matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Padres vs. Blue Jays Game-Day Updates and Essential Details

Thursday's MLB action between the Blue Jays and Padres at Rogers Centre is scheduled to start at 1:07PM ET.

• Who: San Diego Padres vs. Toronto Blue Jays
• Date: Thursday, May 22, 2025
• Time: 1:07PM ET/10:07AM PT
• Venue: Rogers Centre

Dimers.com's comprehensive preview of Thursday's Padres vs. Blue Jays matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Toronto picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 51% win probability, will likely beat the Blue Jays on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Blue Jays insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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