Padres vs. Cardinals Prediction: St. Louis Predicted to Win Thursday's MLB Matchup [7/24/2025]

The St. Louis Cardinals will face the San Diego Padres in MLB action at Busch Stadium on Thursday, commencing at 7:45PM ET.

The Cardinals will have Sonny Gray (9-4, 4.04 ERA) as their starting pitcher, pitting him against Yu Darvish (0-2, 6.08 ERA) for the Padres.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Padres vs. Cardinals predictions page.

Cardinals vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Padres and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 56% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 62% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.

Padres vs. Cardinals Odds [7/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Cardinals
Run Line	+1.5 (-160)	-1.5 (+144)
Moneyline	+130	-154
Total	o7.5 (-115)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Padres vs. Cardinals matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Padres vs. Cardinals Game-Day Updates and Essential Details

Thursday's MLB matchup between the Cardinals and Padres at Busch Stadium is scheduled to commence at 7:45PM ET.

• Who: San Diego Padres vs. St. Louis Cardinals
• Date: Thursday, July 24, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Thursday's Padres vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting set to launch on December 1, 2025, Dimers is where smart bettors turn for the latest news and the best MO sports betting promos.

Conclusion

We predict the Cardinals, with a 56% win probability, will likely beat the Padres on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.