Padres vs. Cardinals Prediction: St. Louis Predicted to Win Sunday's MLB Matchup [7/27/2025]

The St. Louis Cardinals and San Diego Padres are scheduled to meet in MLB action at Busch Stadium on Sunday, starting at 2:15PM ET.

Michael McGreevy (2-1, 3.49 ERA) will be on the bump for the Cardinals, up against Stephen Kolek (3-5, 4.28 ERA) for the Padres.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Padres-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 53%, while the Padres have 47%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Padres vs. Cardinals predictions page.

Cardinals vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Sunday's MLB game between the Padres and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 53% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Padres vs. Cardinals Odds [7/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Cardinals
Run Line	+1.5 (-190)	-1.5 (+160)
Moneyline	+108	-124
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Padres vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Padres vs. Cardinals Game-Day Updates and Essential Details

Sunday's MLB matchup between the Cardinals and Padres at Busch Stadium is scheduled to begin at 2:15PM ET.

• Who: San Diego Padres vs. St. Louis Cardinals
• Date: Sunday, July 27, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Sunday's Padres vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri launching on December 1, 2025, Dimers has everything you need—from the latest news and the best pre-registration offers in MO.

Conclusion

We predict the Cardinals, with a 53% win probability, will likely beat the Padres on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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