Padres vs. Cardinals Prediction: St. Louis Predicted to Win Saturday's MLB Matchup [7/26/2025]

The St. Louis Cardinals will square off with the San Diego Padres in MLB action at Busch Stadium on Saturday, starting at 7:15PM ET.

Matthew Liberatore (6-7, 4.13 ERA) will start for the Cardinals, while the Padres have opted for Randy Vásquez (3-4, 3.73 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Padres vs. Cardinals predictions page.

Cardinals vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Saturday's MLB matchup between the Padres and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 58% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 60% chance of covering the run line, while the 9-run over/under has a 52% chance of staying under.

Padres vs. Cardinals Odds [7/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Cardinals
Run Line	+1.5 (-160)	-1.5 (+138)
Moneyline	+120	-142
Total	o9 (-119)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Padres vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Cardinals Game-Day Updates and Essential Details

Saturday's MLB matchup between the Cardinals and Padres at Busch Stadium is scheduled to start at 7:15PM ET.

• Who: San Diego Padres vs. St. Louis Cardinals
• Date: Saturday, July 26, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Saturday's Padres vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 58% win probability, will likely beat the Padres on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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