Padres vs. Cardinals Prediction: San Diego Predicted to Win Friday's MLB Matchup [7/25/2025]

The St. Louis Cardinals and San Diego Padres will lock horns in MLB action at Busch Stadium on Friday, starting at 7:15PM ET.

The Cardinals will have Miles Mikolas (5-7, 5.20 ERA) as their starting pitcher, while the Padres are going with Nick Pivetta (10-2, 2.81 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Padres vs. Cardinals predictions page.

Cardinals vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's MLB game between the Padres and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Padres a 55% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the 8.5-run over/under has a 52% chance of going over.

Padres vs. Cardinals Odds [7/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Cardinals
Run Line	-1.5 (+135)	+1.5 (-156)
Moneyline	-130	+110
Total	o8.5 (-114)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Padres vs. Cardinals matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Padres vs. Cardinals Game-Day Updates and Essential Details

Friday's MLB action between the Cardinals and Padres at Busch Stadium is scheduled to commence at 7:15PM ET.

• Who: San Diego Padres vs. St. Louis Cardinals
• Date: Friday, July 25, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Friday's Padres vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 55% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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