Padres vs. Mariners prediction: Seattle favored to win Wednesday's MLB matchup [8/27/2025]

The Seattle Mariners will square off with the San Diego Padres in MLB action at T-Mobile Park on Wednesday, beginning at 4:10PM ET.

The Mariners will send Bryan Woo (11-7, 2.94 ERA) to the mound, while the Padres are going with Yu Darvish (3-3, 5.36 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Mariners as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Padres-Mariners game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 56%, with the Padres at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Mariners predictions page.

Mariners vs. Padres prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Padres and Mariners 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Mariners a 56% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.

Padres vs. Mariners odds [8/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Mariners
Run Line	+1.5 (-170)	-1.5 (+145)
Moneyline	+129	-150
Total	o7.5 (-109)	u7.5 (+102)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Mariners picks and best bets

Our model's biggest edge in today's Padres vs. Mariners matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Padres vs. Mariners game-day updates and essential details

Wednesday's MLB game between the Mariners and Padres at T-Mobile Park is scheduled to begin at 4:10PM ET.

• Who: San Diego Padres vs. Seattle Mariners
• Date: Wednesday, August 27, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: T-Mobile Park

Dimers.com's in-depth preview of Wednesday's Padres vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mariners, with a 56% win probability, will likely beat the Padres on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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