Padres vs. Mariners prediction: San Diego favored to win Tuesday's MLB matchup [8/26/2025]

The Seattle Mariners will take on the San Diego Padres, in what is expected to be a tight MLB game, at T-Mobile Park on Tuesday, commencing at 9:40PM ET.

The Mariners will start Luis Castillo (8-7, 3.57 ERA), while the Padres will counter with Dylan Cease (6-11, 4.71 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Mariners predictions page.

Mariners vs. Padres prediction: Who will win?

Using innovative machine learning and data analysis, we have simulated the result of Tuesday's MLB matchup between the Padres and Mariners 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 51% chance of beating the Mariners.

According to our model, the 8-run over/under has a 51% chance of going over.

Padres vs. Mariners odds [8/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Mariners
Moneyline	-104	-112
Total	o8 (-110)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Mariners picks and best bets

Our model's biggest edge in today's Padres vs. Mariners matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Padres vs. Mariners game-day updates and essential details

Tuesday's MLB matchup between the Mariners and Padres at T-Mobile Park is scheduled to commence at 9:40PM ET.

• Who: San Diego Padres vs. Seattle Mariners
• Date: Tuesday, August 26, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: T-Mobile Park

Dimers.com's in-depth preview of Tuesday's Padres vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 51% win probability, will likely beat the Mariners on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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